Sadrieh Nakissa, Brower James, Yu Lawrence, Doub William, Straughn Arthur, Machado Stella, Pelsor Frank, Martin Emmanuelle Saint, Moore Terry, Reepmeyer John, Toler Duckhee, Nguyenpho Agnes, Roberts Rosemary, Schuirmann Donald J, Nasr Moheb, Buhse Lucinda
Food and Drug Administration, 5515 Security Lane, Rockville, Maryland, 20852, USA.
Pharm Res. 2005 Oct;22(10):1747-56. doi: 10.1007/s11095-005-6387-x. Epub 2005 Sep 22.
These studies evaluated the ability of common household food and drink products to mask the bitter taste of three selected anti-terrorism drugs.
Three anti-terrorism drugs (doxycycline, ciprofloxacin hydrochloride, and potassium iodide) were mixed with a variety of common household food and drinks, and healthy adult volunteers evaluated the resulting taste and aftertaste. In parallel, the ASTREE Electronic Tongue was used to evaluate taste combinations. Stability of the mixtures over time was monitored, as was the dosage uniformity across preparations.
Foods and drinks were identified that satisfactorily masked the bitter flavor of each drug. Dose uniformity and stability were also acceptable over the range studied, although some combinations were significantly less stable than others. The electronic tongue was able to differentiate between tastes, but ranked masking agents in a different order than human volunteers.
Doxycycline, potassium iodide, and ciprofloxacin, which are stockpiled in solid tablet form, can conveniently be prepared into more palatable formulations, using common household foods and drinks. The electronic tongue can be used to perform an initial screening for palatability.
这些研究评估了常见家用食品和饮料产品掩盖三种选定反恐药物苦味的能力。
将三种反恐药物（强力霉素、盐酸环丙沙星和碘化钾）与多种常见家用食品和饮料混合，健康成年志愿者对 resulting 味道和余味进行评估。同时，使用 ASTREE 电子舌评估味道组合。监测混合物随时间的稳定性以及制剂间的剂量均匀性。
确定了能令人满意地掩盖每种药物苦味的食品和饮料。在所研究的范围内，剂量均匀性和稳定性也可接受，尽管有些组合的稳定性明显低于其他组合。电子舌能够区分味道，但对掩味剂的排名顺序与人类志愿者不同。
以固体片剂形式储存的强力霉素、碘化钾和环丙沙星，可以方便地使用常见家用食品和饮料制成更可口的制剂。电子舌可用于对适口性进行初步筛选。
