Meier A, Hertzberg H
Institut für Parasitologie der Universität Zürich.
Schweiz Arch Tierheilkd. 2005 Sep;147(9):389-96. doi: 10.1024/0036-7281.147.9.389.
The occurrence of anthelmintic resistance in strongyles was investigated in 440 horses on 90 farms in Switzerland. The egg hatch assay suggested that benzimidazole (BZ)-resistance was present in 40 of 82 farms (49%). Faecal egg count reduction after pyrantel-treatment was above 96% in 14 of 15 farms. In the remaining farm the efficacy was only 80%. Ivermectin efficacy was investigated on 5 farms and the efficacy was recorded at 98-100%. Faecal cultures undertaken after treatment revealed almost exclusively larvae of the family Cyathostominae. Data about management practices, pasture hygiene and anthelmintic usage were obtained with a questionnaire. Horses were treated on average 3.5 times per year. In 75% of the farms BZ were a component of the seasonal treatment schedule. Only the use of BZ had a significant correlation with the presence of BZ-resistance (P < 0.01). Recommendations for the control of equine strongyles should include measures that minimize the risk of resistance developing against remaining effective anthelmintics.
在瑞士90个农场的440匹马中调查了圆线虫抗驱虫药情况。虫卵孵化试验表明，82个农场中有40个（49%）存在苯并咪唑（BZ）耐药性。在15个农场中，有14个农场使用噻嘧啶治疗后粪便虫卵计数减少率高于96%。在其余农场，疗效仅为80%。在5个农场研究了伊维菌素的疗效，记录的疗效为98%-100%。治疗后进行的粪便培养几乎只发现了杯口线虫科的幼虫。通过问卷调查获取了有关管理措施、牧场卫生和驱虫药使用的数据。马匹平均每年接受3.5次治疗。在75%的农场中，BZ是季节性治疗方案的一个组成部分。只有BZ的使用与BZ耐药性的存在有显著相关性（P<0.01）。控制马圆线虫的建议应包括采取措施，尽量降低对其余有效驱虫药产生耐药性的风险。
