Cucchiara S, Minella R, Riezzo G, Vallone G, Vallone P, Castellone F, Auricchio S
Department of Pediatrics, 2nd School of Medicine, University of Naples, Italy.
Dig Dis Sci. 1992 Jul;37(7):1136-40. doi: 10.1007/BF01300300.
Three children (ages 5, 7.6, and 8 years), with recurrent unexplained upper abdominal symptoms such as vomiting, epigastric pain, anorexia, early satiety and without structural or mucosal abnormalities of gastrointestinal tract, underwent electrogastrography (EGG)--recording of gastric electrical activity using cutaneous electrodes positioned on the epigastric region and connected to a recording polygraph. Frequency of EGG signals was analyzed by fast Fourier transform. Significant changes of fasting and fed gastric myoelectrical activity (tachygastria, bradygastria, flatline pattern) were recorded in the three patients; furthermore, gastric emptying (GE) of a solid-liquid mixed meal, measured by ultrasonography, was significantly prolonged in them. A follow-up study was carried out after an eight-week course with oral cisapride: in all patients symptoms improved, GE time normalized, and EGG analysis showed normal electrical rhythm. It is suggested that gastric dysrhythmias can play a pathogenetic role in patients with functional gastrointestinal symptoms and that symptomatic improvement is accompanied by normalization of gastric electrical rhythm.
三名儿童（年龄分别为5岁、7.6岁和8岁）反复出现不明原因的上腹部症状，如呕吐、上腹部疼痛、厌食、早饱，且胃肠道无结构或黏膜异常，他们接受了胃电图（EGG）检查——使用置于上腹部区域的皮肤电极记录胃电活动，并连接到记录式多导生理记录仪。通过快速傅里叶变换分析EGG信号频率。三名患者均记录到空腹和进食后胃肌电活动的显著变化（胃动过速、胃动过缓、基线模式）；此外，通过超声测量，他们的固液混合餐胃排空（GE）明显延长。在口服西沙必利进行为期八周的疗程后进行了随访研究：所有患者症状均有改善，GE时间恢复正常，EGG分析显示电节律正常。提示胃节律紊乱可能在功能性胃肠道症状患者中起致病作用，且症状改善伴随着胃电节律的正常化。
