对乙酰氨基酚从帕拉马克斯、必理通和索普赛定中的吸收情况。
Paracetamol absorption from Paramax, Panadol and Solpadeine.
作者信息
Dougall J R, Cunningham B, Nimmo W S
出版信息
Br J Clin Pharmacol. 1983 Apr;15(4):487-9. doi: 10.1111/j.1365-2125.1983.tb01534.x.
Abstract
Plasma paracetamol concentrations were measured after oral administration of three pharmaceutical preparations to four healthy volunteers. The formulations were Paramax (paracetamol with metoclopramide), Solpadeine (paracetamol with codeine and caffeine) and Panadol (paracetamol alone). After Solpadeine, concentrations at 15 min were significantly higher than after Panadol. Absorption of paracetamol from Paramax tablets did not differ significantly from Solpadeine or Panadol.
摘要
对四名健康志愿者口服三种药物制剂后，测定了血浆对乙酰氨基酚浓度。这些制剂分别是帕拉马克斯（对乙酰氨基酚与胃复安）、索普待因（对乙酰氨基酚与可待因和咖啡因）和必理通（仅含对乙酰氨基酚）。服用索普待因后，15分钟时的浓度显著高于服用必理通后。帕拉马克斯片剂中对乙酰氨基酚的吸收与索普待因或必理通没有显著差异。
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