Noguchi Hiroshi, Gompper Gerhard
Institut für Festkörperforschung, Forschungszentrum Jülich, 52425 Jülich, Germany.
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14159-64. doi: 10.1073/pnas.0504243102. Epub 2005 Sep 26.
The dynamics of fluid vesicles and red blood cells (RBCs) in cylindrical capillary flow is studied by using a three-dimensional mesoscopic simulation approach. As flow velocity increases, a model RBC is found to transit from a nonaxisymmetric discocyteto an axisymmetric parachute shape (coaxial with the flow axis), while a fluid vesicle is found to transit from a discocyte to a prolate ellipsoid. Both shape transitions reduce the flow resistance. The critical velocities of the shape transitions are linearly dependent on the bending rigidity and on the shear modulus of the membrane. Slipper-like shapes of the RBC model are observed around the transition velocities. Our results are in good agreement with experiments on RBCs.
采用三维介观模拟方法研究了圆柱形毛细管流中流体囊泡和红细胞(RBCs)的动力学。随着流速增加,发现模型红细胞从非轴对称的盘状细胞转变为轴对称的降落伞形状(与流动轴同轴),而流体囊泡则从盘状细胞转变为长椭球体。两种形状转变都降低了流动阻力。形状转变的临界速度与膜的弯曲刚度和剪切模量呈线性相关。在转变速度附近观察到红细胞模型的拖鞋状形状。我们的结果与红细胞实验结果吻合良好。