Shimbo Daichi, Chaplin William, Crossman Daniel, Haas Donald, Davidson Karina W
The Behavioral Cardiovascular Health and Hypertension Program, Columbia University Medical Center, USA.
Am J Cardiol. 2005 Oct 1;96(7):1016-21. doi: 10.1016/j.amjcard.2005.05.064.
Inflammatory biomarkers and depression have been proposed as novel coronary heart disease (CHD) risk markers. However, prospective studies have rarely assessed these 2 candidate CHD risk markers simultaneously in predicting incident CHD events. Therefore, although depression and elevated inflammatory biomarkers frequently covary, it is unclear how these risk markers relate to each other and to CHD event onset. The elucidation of these causal pathways has important clinical implications for patients who are depressed and/or have elevated inflammatory biomarkers. In this review, the publications examining the relations among depression, inflammation, and CHD events are discussed.
炎症生物标志物和抑郁症已被提出作为新型冠心病（CHD）风险标志物。然而，前瞻性研究很少同时评估这两种冠心病风险候选标志物对冠心病事件发生的预测作用。因此，尽管抑郁症和炎症生物标志物水平升高常常同时出现，但尚不清楚这些风险标志物之间以及它们与冠心病事件发生之间的关系。阐明这些因果途径对患有抑郁症和/或炎症生物标志物水平升高的患者具有重要的临床意义。在这篇综述中，将讨论研究抑郁症、炎症和冠心病事件之间关系的相关出版物。
