Cherpitel C, Bond J, Ye Y, Room R, Poznyak V, Rehm J, Peden M
Alcohol Research Group, Berkeley, CA 94709, USA.
Emerg Med J. 2005 Oct;22(10):689-95. doi: 10.1136/emj.2004.016865.
The purpose of this study was to analyse the validity of clinical assessment of alcohol intoxication (ICD-10 Y91) compared with estimated blood alcohol concentration (BAC) using a breath analyser (ICD-10 Y90) among patients in the emergency room (ER).
Representative samples of ER patients reporting within six hours of injury (n = 4798) from 12 countries comprising the WHO Collaborative Study on Alcohol and Injuries were breath analysed and assessed blindly for alcohol intoxication at the time of ER admission. Data were analysed using Kendall's Tau-B to measure concordance of clinical assessment and BAC, and meta analysis to determine heterogeneity of effect size.
Raw agreement between the two measures was 86% (Tau-B 0.68), but was lower among those reporting drinking in the six hours prior to injury (raw agreement 39%; Tau-B 0.32). No difference was found by gender or for timing of clinical assessment in relation to breath analysis. Patients positive for tolerance or dependence were more likely to be assessed as intoxicated at low levels of BAC. Estimates were homogeneous across countries only for females and for those negative for alcohol dependence.
Clinical assessment is moderately concordant with level of BAC, but in those patients who have actually been drinking within the last six hours the concordance was much less, possibly because, in part, of a tendency on the part of clinicians to assign some level of intoxication to anyone who appeared to have been drinking.
本研究旨在分析在急诊室(ER)患者中,将酒精中毒的临床评估(国际疾病分类第十版Y91)与使用呼气分析仪测定的估计血液酒精浓度(BAC,国际疾病分类第十版Y90)相比较的有效性。
来自12个国家的世界卫生组织酒精与伤害合作研究中,在受伤后6小时内就诊的急诊患者代表性样本(n = 4798)接受了呼气分析,并在急诊入院时对酒精中毒情况进行了盲法评估。使用肯德尔tau - B系数分析数据,以衡量临床评估与BAC之间的一致性,并通过荟萃分析确定效应大小的异质性。
两种测量方法的原始一致性为86%(tau - B 0.68),但在受伤前6小时内报告饮酒的患者中该一致性较低(原始一致性39%;tau - B 0.32)。未发现性别差异,也未发现临床评估时间与呼气分析之间存在差异。对耐受性或依赖性呈阳性的患者在BAC水平较低时更有可能被评估为中毒。仅在女性和酒精依赖呈阴性的患者中,各国的估计结果具有同质性。
临床评估与BAC水平具有中等程度的一致性,但在过去6小时内实际饮酒的患者中,一致性要低得多,这可能部分是因为临床医生倾向于将一定程度的中毒诊断给任何看似饮酒的人。