Astrup A, Buemann B, Christensen N J, Toubro S, Thorbek G, Victor O J, Quaade F
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Metabolism. 1992 Jul;41(7):686-8. doi: 10.1016/0026-0495(92)90304-s.
Treatment with beta 2-agonists promotes fat loss and muscle growth in numerous species, but human studies are lacking. We studied the effect of a compound with beta 2-agonistic properties (ephedrine 20 mg/caffeine 200 mg [E + C]). Fourteen obese women were treated with a 4.2-MJ/d diet and either E + C or placebo (P) three times per day for 8 weeks in a double-blind study. Weight-loss was not different in the groups, but the E + C group lost 4.5 kg more body fat and 2.8 kg less fat-free mass (FFM). The decrease in 24-hour energy expenditure (EE) seen in the P group was 10% at day 1 and 13% at day 56, but was only 7% and 8% in the treated group (P = .044). The higher EE in the E +C group was entirely covered by fat oxidation. These findings provide evidence that promotion of fat loss and preservation of FFM during weight reduction may also be achieved pharmacologically in humans.
β2 激动剂治疗可促进多种物种的脂肪减少和肌肉生长，但缺乏人体研究。我们研究了一种具有β2 激动特性的化合物（麻黄碱 20 毫克/咖啡因 200 毫克 [E + C]）的效果。在一项双盲研究中，14 名肥胖女性接受了每天 4.2 兆焦耳的饮食，并每天三次服用 E + C 或安慰剂（P），持续 8 周。两组的体重减轻没有差异，但 E + C 组的体脂减少了 4.5 千克，去脂体重（FFM）减少了 2.8 千克。安慰剂组在第 1 天 24 小时能量消耗（EE）下降了 10%，在第 56 天下降了 13%，但治疗组仅下降了 7%和 8%（P = 0.044）。E + C 组较高的能量消耗完全由脂肪氧化提供。这些发现提供了证据，表明在体重减轻期间促进脂肪减少和保留去脂体重在人体中也可以通过药物实现。
