Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, USA.
Obesity (Silver Spring). 2013 Oct;21(10):1991-6. doi: 10.1002/oby.20416. Epub 2013 Jun 11.
To evaluate the effects of combination caffeine/ephedrine and leptin A-200 on visceral fat mass and weight loss over 24 weeks.
In this randomized, double-blind, parallel-arm trial, 90 obese subjects received one of the three treatments for 24 weeks: 200 mg caffeine/20 mg ephedrine t.i.d. (CE), leptin A-200 (recombinant methionyl human Fc-leptin, 20 mg q.d.) (L), or combination leptin A-200 and caffeine/ephedrine (LCE). Outcomes included change in weight, visceral fat mass by computed tomography, lean mass and fat mass by dual energy X-ray absorptiometry.
Groups treated with CE and LCE lost significant amounts of weight (-5.9 ± 1.2% and -6.5 ± 1.1%, P < 0.05) and whole body fat mass (-9.6 ± 2.4% and -12.4 ± 2.3%, P < 0.05) compared to leptin only group. Only treatment with LCE significantly reduced visceral fat mass (-11.0 ± 3.3%, P < 0.05). There were no differences in lean mass between treatment groups.
Our study provides evidence that CE is a modestly effective weight loss agent and produces significant reductions in fat mass. Leptin A-200 was not effective in producing weight loss and did not have any significant additive or synergistic actions when combined with CE.
评估组合咖啡因/麻黄碱和瘦素 A-200 对内脏脂肪质量和 24 周体重减轻的影响。
在这项随机、双盲、平行臂试验中，90 名肥胖受试者接受了三种治疗中的一种，持续 24 周：200mg 咖啡因/20mg 麻黄碱 tid（CE）、瘦素 A-200（重组甲硫氨酸人 Fc-瘦素，20mg qd）（L）或组合瘦素 A-200 和咖啡因/麻黄碱（LCE）。结果包括体重变化、计算机断层扫描测量的内脏脂肪质量、双能 X 射线吸收法测量的瘦体重和脂肪质量。
接受 CE 和 LCE 治疗的组体重显著减轻（-5.9±1.2%和-6.5±1.1%，P<0.05）和全身脂肪质量减少（-9.6±2.4%和-12.4±2.3%，P<0.05）与仅接受瘦素治疗的组相比。只有 LCE 治疗组显著减少了内脏脂肪质量（-11.0±3.3%，P<0.05）。各组之间的瘦体重无差异。
我们的研究提供了证据，表明 CE 是一种适度有效的减肥药物，可显著减少脂肪质量。瘦素 A-200 不能有效减肥，与 CE 联合使用时没有任何显著的附加或协同作用。
