口服葡糖基橙皮苷和咖啡因组合对健康的中度肥胖受试者有抗肥胖作用：一项随机双盲安慰剂对照试验。
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial.
作者信息
Ohara Tatsuya, Muroyama Koutarou, Yamamoto Yoshihiro, Murosaki Shinji
机构信息
Research & Development Institute, House Wellness Foods Corporation, 3-20 Imoji, Itami, Hyogo, 664-0011, Japan.
出版信息
Nutr J. 2016 Jan 19;15:6. doi: 10.1186/s12937-016-0123-7.
BACKGROUND
We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. The aim of this study is to evaluate the anti-obesity effect of G-hesperidin plus caffeine on body fat and serum TG in healthy subjects with moderately high body mass index (BMI) and serum TG. Since we considered that there are individual differences in caffeine sensitivity, we conducted dose-finding study of caffeine combined with G-hesperidin.
METHODS
Seventy-five healthy subjects with moderately high BMI (24-30 kg/m(2)) and serum TG (100-250 mg/dl) were divided and assigned to 12-week intervention with daily intakes of 500 mg of G-hesperidin with or without 25, 50, or 75 mg of caffeine, or placebo in a randomized double-blind placebo-controlled design .
RESULTS
After intervention, decreases in abdominal fat area (AFA), especially subcutaneous fat area (SFA), were significantly greater in the G-hesperidin with 50-mg caffeine group (AFA:-8.4 ± 21.9 v.s. 16.3 ± 34.1 cm(2); p < 0.05, SFA: -9.3 ± 17.1 v.s. 11.2 ± 18.3 cm(2); p < 0.01) and in the G-hesperidin with 75-mg caffeine group (AFA:-17.0 ± 31.4 v.s. 16.3 ± 34.1 cm(2); p < 0.01, SFA: -12.4 ± 18.7 v.s. 11.2 ± 18.3 cm(2); p < 0.01) than in the placebo group. Fat-decreasing effects of G-hesperidin were enhanced dose-dependently by caffeine addition. BMI decreases were significantly greater in the G-hesperidin with 75-mg caffeine group than in the placebo group (-0.56 ± 0.74 v.s. -0.02 ± 0.58 kg/m(2); p < 0.05). G-hesperidin with/without caffeine had no effect on serum TG (p > 0.05 v.s. placebo).
CONCLUSIONS
These data suggested that a combination of 500-mg G-hesperidin with 50- or 75-mg caffeine may be useful for the prevention or treatment of obesity.
TRIAL REGISTRATION
UMIN Clinical Trials Registry 000019241 .
背景
我们之前已经表明，葡糖基橙皮苷（G-橙皮苷）与咖啡因联合使用可减少体内脂肪堆积，而单独使用G-橙皮苷或咖啡因对高脂饮食诱导的小鼠肥胖几乎没有影响。本研究的目的是评估G-橙皮苷与咖啡因联合使用对体重指数（BMI）和血清甘油三酯（TG）处于中度偏高的健康受试者体内脂肪和血清TG的抗肥胖作用。由于我们认为咖啡因敏感性存在个体差异，因此我们进行了咖啡因与G-橙皮苷联合使用的剂量探索研究。
方法
75名BMI（24 - 30 kg/m²）和血清TG（100 - 250 mg/dl）中度偏高的健康受试者被随机分为4组，采用双盲安慰剂对照设计，进行为期12周的干预，分别每日摄入500 mg G-橙皮苷加25、50或75 mg咖啡因，或安慰剂。
结果
干预后，50 mg咖啡因组（腹部脂肪面积（AFA）：-8.4 ± 21.9 vs. 16.3 ± 34.1 cm²；p < 0.05，皮下脂肪面积（SFA）：-9.3 ± 17.1 vs. 11.2 ± 18.3 cm²；p < 0.01）和75 mg咖啡因组（AFA：-17.0 ± 31.4 vs. 16.3 ± 34.1 cm²；p < 0.01，SFA：-12.4 ± 18.7 vs. 11.2 ± 18.3 cm²；p < 0.01）的腹部脂肪面积，尤其是皮下脂肪面积的减少幅度显著大于安慰剂组。添加咖啡因后，G-橙皮苷的减脂效果呈剂量依赖性增强。75 mg咖啡因组的BMI下降幅度显著大于安慰剂组（-0.56 ± 0.74 vs. -0.02 ± 0.58 kg/m²；p < 0.05）。G-橙皮苷加或不加咖啡因对血清TG均无影响（与安慰剂相比，p > 0.05）。
结论
这些数据表明，500 mg G-橙皮苷与50或75 mg咖啡因联合使用可能对肥胖的预防或治疗有用。
试验注册
日本大学医学情报网络临床试验注册中心000019241 。
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