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枯草芽孢杆菌的核黄素操纵子:调控区域不同寻常的对称排列。

Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region.

作者信息

Kil Y V, Mironov V N, Kreneva R A, Perumov D A

机构信息

Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physics Institute of the Academy of Sciences of the USSR, Gatchina.

出版信息

Mol Gen Genet. 1992 Jun;233(3):483-6. doi: 10.1007/BF00265448.

Abstract

Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides +37 and +159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/C-rich sequences that symmetrically blank a short inverted repeat.

摘要

导致枯草芽孢杆菌核黄素过量产生的17个顺式显性突变定位在相对于核黄素操纵子转录起始位点核苷酸+37至+159之间的区域。该区域的调控序列结构异常。其主要部分是富含A/T和G/C的序列簇,这些序列簇对称地环绕着一个短的反向重复序列。

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