经鼻内接种的改良活犬2b型细小病毒疫苗在具有母源抗体的幼犬中的免疫原性。
Immunogenicity of an intranasally administered modified live canine parvovirus type 2b vaccine in pups with maternally derived antibodies.
作者信息
Martella Vito, Cavalli Alessandra, Decaro Nicola, Elia Gabriella, Desario Costantina, Campolo Marco, Bozzo Giancarlo, Tarsitano Elvira, Buonavoglia Canio
机构信息
Department of Animal Health and Well-Being, Faculty of Veterinary Medicine, University of Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy.
出版信息
Clin Diagn Lab Immunol. 2005 Oct;12(10):1243-5. doi: 10.1128/CDLI.12.10.1243-1245.2005.
Abstract
The ability of a modified live canine parvovirus type 2b vaccine to elicit active immunization in pups with maternally derived antibodies (MDA) by intranasal administration was evaluated. The vaccine induced seroconversion in 100% of pups with MDA titers of < or = 80 and in 51.6% of pups with titers between 160 and 320.
摘要
评估了一种改良的犬细小病毒2b型活疫苗通过鼻内给药在具有母源抗体（MDA）的幼犬中引发主动免疫的能力。该疫苗在MDA滴度≤80的幼犬中诱导血清转化的比例为100%，在滴度介于160至320之间的幼犬中诱导血清转化的比例为51.6%。
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