Schnabel T, Zamboglou N, Kolotas C, Jiménez W, Strehl H, Schmitt G
Department of Radiation Oncology, Heinrich-Heine-University, Düsseldorf.
Strahlenther Onkol. 1992 Jun;168(6):318-21.
From 1990 to 1991 15 patients with advanced head and neck carcinomas underwent hyperfractionated accelerated radiotherapy (2 x 1.6 Gy/day, five days/week, total dose 64.0 to 67.2 Gy) and simultaneous intravenous application of Carboplatin (60 mg/m2, days 1 to 5 and 29 to 33) in a pilot study. Eleven patients had T4 and four had T3 tumours. At the end of treatment twelve patients had a complete tumour remission and in the others a partial tumour involution was seen. Although acute side-effects were more pronounced compared to conventional irradiation this treatment regimen is feasible and the initial complete remission rate of 80% is encouraging.
1990年至1991年，在一项初步研究中，15例晚期头颈癌患者接受了超分割加速放疗（每天2次，每次1.6 Gy，每周5天，总剂量64.0至67.2 Gy），并同时静脉注射卡铂（60 mg/m²，第1至5天和第29至33天）。11例患者为T4期肿瘤，4例为T3期肿瘤。治疗结束时，12例患者肿瘤完全缓解，其他患者可见部分肿瘤消退。尽管与传统放疗相比，急性副作用更为明显，但该治疗方案是可行的，80%的初始完全缓解率令人鼓舞。
