Volling P, Staar S, Eckel H E, Müller R P
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universität zu Köln.
Laryngorhinootologie. 1994 Oct;73(10):511-7. doi: 10.1055/s-2007-997184.
Until now, radical irradiation has been the treatment of choice for patients with unresectable squamous cell carcinomas of the head and neck. In spite of improved radiation techniques, conventional radiotherapy remains mainly palliative for patients with advanced and unresectable disease stages. Our own results with accelerated radiotherapy (2 x 2.1 Gy/day, day 1-4 in week 1, 2, 5 and 6, total dose of 67.2 Gy) and simultaneous chemotherapy with carboplatin (50 mg/m2/treatment day) suggest that combined radiochemotherapy might improve the poor results achieved with conventional radiotherapy or sequential chemoradiotherapy in these patients. However, further studies are necessary to clarify whether modified radiotherapy or simultaneous chemotherapy or the combination of both are the reason for the improved treatment results. Furthermore, accelerated radiotherapy and simultaneous chemotherapy should also be investigated as an adjuvant postoperative treatment modality in primary resectable patients with advanced stage of disease to improve their poor prognosis.
到目前为止，根治性放疗一直是不可切除的头颈部鳞状细胞癌患者的首选治疗方法。尽管放疗技术有所改进，但对于晚期和不可切除疾病阶段的患者，传统放疗仍主要是姑息性的。我们采用加速放疗（2×2.1 Gy/天，第1、2、5和6周的第1 - 4天，总剂量67.2 Gy）和卡铂同步化疗（50 mg/m²/治疗日）的结果表明，联合放化疗可能会改善这些患者采用传统放疗或序贯放化疗所取得的不佳疗效。然而，需要进一步研究以阐明改良放疗、同步化疗或两者联合是否是治疗效果改善的原因。此外，对于疾病晚期的原发性可切除患者，加速放疗和同步化疗也应作为辅助术后治疗方式进行研究，以改善其不良预后。
