Kamarajan Chella, Porjesz Bernice, Jones Kevin, Chorlian David, Padmanabhapillai Ajayan, Rangaswamy Madhavi, Stimus Arthur, Begleiter Henri
Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA.
Biol Psychiatry. 2006 Apr 1;59(7):625-34. doi: 10.1016/j.biopsych.2005.08.017. Epub 2005 Oct 6.
Event-related oscillations (EROs) are increasingly being used to assess neurocognitive functioning in normal and clinical populations. The current study compares different frequency activities in offspring of alcoholics (OA) and in normal control subjects (NC) to examine whether the OA group exhibits any abnormality in oscillatory activity while performing a Go/NoGo task.
The S-transform algorithm was employed to decompose the electroencephalographic (EEG) signals into different time-frequency bands, and the oscillatory responses in the P300 time window (300-700 milliseconds) were statistically analyzed in both groups.
The OA group manifested significantly decreased activity in delta (1-3 Hz), theta (4-7 Hz), and alpha1 (8-9 Hz) bands during the NoGo condition, as well as reduced delta and theta activity during the Go condition. This reduction was more prominent in the NoGo than in the Go condition.
The decreased response in delta, theta, and alpha1 oscillations, especially during the NoGo condition in high-risk individuals, is perhaps suggestive of cognitive and neural disinhibition and may serve as an endophenotypic marker in the development of alcoholism and/or other disinhibitory disorders.
事件相关振荡（EROs）越来越多地用于评估正常人群和临床人群的神经认知功能。本研究比较了酗酒者后代（OA）和正常对照者（NC）的不同频率活动，以检查OA组在执行Go/NoGo任务时振荡活动是否存在异常。
采用S变换算法将脑电图（EEG）信号分解为不同的时频带，并对两组在P300时间窗（300 - 700毫秒）内的振荡反应进行统计分析。
OA组在NoGo条件下，δ（1 - 3Hz）、θ（4 - 7Hz）和α1（8 - 9Hz）频段的活动显著降低，在Go条件下δ和θ活动也减少。这种减少在NoGo条件下比在Go条件下更明显。
δ、θ和α1振荡反应的降低，尤其是在高风险个体的NoGo条件下，可能提示认知和神经抑制解除，可作为酒精中毒和/或其他抑制解除障碍发展中的一种内表型标记。
