Sopher Aviva B, Grigoriev Galina, Laura Diana, Cameo Tamara, Lerner Jodi P, Chang R Jeffrey, McMahon Donald J, Oberfield Sharon E
J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1175-9. doi: 10.1515/jpem-2014-0128.
This study aimed to [1] confirm that nonobese adolescents with polycystic ovary syndrome (PCOS) have higher anti-Mullerian hormone (AMH) than controls; [2] examine the relationship of AMH with PCOS features and hormonal profile; and [3] approximate an AMH value that discriminates between adolescents with PCOS and controls.
Case-control study.
Subspecialty ambulatory clinic.
Thirty-one nonobese adolescent girls (age 13-21 years), 15 with PCOS diagnosed using the National Institutes of Health (NIH) criteria and 16 healthy control subjects. Subjects and controls were comparable for body mass index z-score, age and ethnicity.
MAIN OUTCOME MEASURE(S): AMH in PCOS subjects and control groups, correlation of AMH with hormonal parameters.
AMH was higher in PCOS subjects (4.4±3.4 ng/mL) than in controls (2.4±1.3 ng/mL), when adjusted for menstrual age. In the entire group (PCOS and controls), AMH correlated with androgens, ovarian size and the presence of polycystic ovary (PCO) appearance. There was no difference in average ovarian size between PCOS (7.1±2.6 cm³) and controls (6.7±1.8 cm³). PCOS subjects were 1.49 times more likely to have AMH >3.4 ng/mL (confidence interval 0.98-2.26 ng/mL).
Our data suggest that AMH may be a useful adjunct in the diagnosis of PCOS in adolescents.
本研究旨在[1]证实患有多囊卵巢综合征（PCOS）的非肥胖青少年的抗苗勒管激素（AMH）水平高于对照组；[2]研究AMH与PCOS特征及激素谱之间的关系；[3]估算一个能够区分患有PCOS的青少年和对照组的AMH值。
病例对照研究。
专科门诊。
31名非肥胖青春期女孩（年龄13 - 21岁），其中15名根据美国国立卫生研究院（NIH）标准诊断为PCOS，16名作为健康对照。受试者和对照组在体重指数z评分、年龄和种族方面具有可比性。
PCOS组和对照组的AMH水平，AMH与激素参数的相关性。
校正月经年龄后，PCOS组受试者的AMH水平（4.4±3.4 ng/mL）高于对照组（2.4±1.3 ng/mL）。在整个研究组（PCOS组和对照组）中，AMH与雄激素、卵巢大小及多囊卵巢（PCO）外观相关。PCOS组（7.1±2.6 cm³）和对照组（6.7±1.8 cm³）的平均卵巢大小无差异。PCOS受试者的AMH>3.4 ng/mL的可能性是对照组的1.49倍（置信区间0.98 - 2.26 ng/mL）。
我们的数据表明，AMH可能有助于青少年PCOS的诊断。
