抗苗勒管激素水平评估在青少年多囊卵巢综合征管理中的应用
Assessment of Anti-Müllerian Hormone Level in Management of Adolescents with Polycystic Ovary Syndrome.
作者信息
Dursun Fatma, Güven Ayla, Yıldız Metin
机构信息
Ümraniye Education and Research Hospital, Clinic of Pediatric Endocrinology, İstanbul, Turkey, Phone: +90 505 267 14 03 E-mail:
出版信息
J Clin Res Pediatr Endocrinol. 2016 Mar 5;8(1):55-60. doi: 10.4274/jcrpe.2338. Epub 2015 Jan 18.
OBJECTIVE
This study was oriented to investigate the benefit of anti-Müllerian hormone (AMH) level in the management of polycystic ovary syndrome (PCOS). To assess the impact of metformin and oral contraceptives (OC) on serum AMH levels in a cohort of adolescents with PCOS.
METHODS
Forty-nine adolescents with PCOS were recruited to the study. Twenty-nine patients without insulin resistance were treated with OC (group 1), and 20 patients with insulin resistance were treated with metformin and OC (group 2). AMH and androgen levels were measured prior to and 6 months after the initiation of treatment.
RESULTS
AMH levels were significantly decreased with treatment in both group 1 (p=0.006) and group 2 (p=0.0048). There was a significant correlation between pre- and post-treatment AMH and left ovarian volume (pretreatment: rho=0.336, p=0.018; post-treatment: rho=0.310, p=0.034).
CONCLUSION
This study investigated two different treatment regimens in adolescents with PCOS and revealed that AMH levels decreased with treatment. AMH levels were correlated with ovarian volume.
目的
本研究旨在探讨抗苗勒管激素（AMH）水平在多囊卵巢综合征（PCOS）管理中的益处。评估二甲双胍和口服避孕药（OC）对一组PCOS青少年血清AMH水平的影响。
方法
招募49名PCOS青少年参与研究。29名无胰岛素抵抗的患者接受OC治疗（第1组），20名有胰岛素抵抗的患者接受二甲双胍和OC治疗（第2组）。在治疗开始前和治疗6个月后测量AMH和雄激素水平。
结果
第1组（p=0.006）和第2组（p=0.0048）治疗后AMH水平均显著降低。治疗前后AMH与左卵巢体积之间存在显著相关性（治疗前：rho=0.336，p=0.018；治疗后：rho=0.310，p=0.034）。
结论
本研究调查了PCOS青少年的两种不同治疗方案，发现治疗后AMH水平降低。AMH水平与卵巢体积相关。
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