Rogers Zora R
Division of Pediatric Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9063, USA.
Hematol Oncol Clin North Am. 2005 Oct;19(5):917-28, viii. doi: 10.1016/j.hoc.2005.08.003.
Priapism, an unwanted painful erection of the penis, is a little discussed but common complication of sickle cell disease. What is known about the prevalence of priapism, efficacy of management approaches, and outcome is drawn primarily from retrospective and single-center reports. Priapism occurs in two patterns: prolonged and stuttering (ie, recurrent brief episodes that resolve spontaneously). If priapism persists for 4 hours or more without detumescence, the patient is at risk for irreversible ischemic penile injury, which may terminate in fibrosis and impotence. Large multicenter studies examining the epidemiology and current treatments and well-organized trials of novel therapies are urgently needed for patients who have sickle cell disease and priapism.
阴茎异常勃起是阴茎不自主的疼痛性勃起，是镰状细胞病较少被讨论但常见的并发症。关于阴茎异常勃起的患病率、治疗方法的疗效及结果，主要来自回顾性研究和单中心报告。阴茎异常勃起有两种类型：持续性和间歇性（即反复出现的短暂发作且能自行缓解）。如果阴茎异常勃起持续4小时或更长时间而未消退，患者有发生不可逆缺血性阴茎损伤的风险，这可能最终导致纤维化和阳痿。对于患有镰状细胞病和阴茎异常勃起的患者，迫切需要大型多中心研究来调查其流行病学和当前治疗方法，以及精心组织的新型疗法试验。
