Emond A M, Holman R, Hayes R J, Serjeant G R
Arch Intern Med. 1980 Nov;140(11):1434-7.
A questionnaire study of Jamaican patients with homozygous sickle cell (SS) disease indicated a 42% prevalence of priapism, with a median age at onset of 21 years. Two predominantly different patterns of priapism were recorded: short "stuttering" episodes lasting less than three hours, with normal consequent sexual function, and severe prolonged attacks (generally more than 24 hours) commonly followed by impotence. Stuttering episodes were frequently a prodrome to a major attack. Over one fourth of those who had suffered priapism had some degree of impotence. Hematologic analysis indicated that priapism was significantly associated with low hemoglobin F levels and high platelet counts. Patients with severe attacks of priapism had lower hemoglobin F levels and reticulocyte count, and a higher mean corpuscular volume, than patients with only stuttering episodes. Priapism and impotence contribute to the morbidity of SS disease more frequently than previously recognized.
一项针对牙买加纯合子镰状细胞（SS）病患者的问卷调查研究表明，阴茎异常勃起的患病率为42%，发病中位年龄为21岁。记录到两种主要不同类型的阴茎异常勃起：持续时间少于三小时的短暂“间歇性”发作，随后性功能正常；严重的持续性发作（通常超过24小时），通常随后出现阳痿。间歇性发作常常是严重发作的前驱症状。超过四分之一曾患阴茎异常勃起的患者有一定程度的阳痿。血液学分析表明，阴茎异常勃起与低血红蛋白F水平和高血小板计数显著相关。与仅有间歇性发作的患者相比，阴茎异常勃起严重发作的患者血红蛋白F水平和网织红细胞计数更低，平均红细胞体积更高。阴茎异常勃起和阳痿比之前认为的更频繁地导致SS病的发病。
