Namiki M, Tagami Y, Yamamoto M, Yamanaka A, Itoh M, Kanoh M
Eye Clinic, Shakai-hoken Kobe Central Hospital, Japan.
Nippon Ganka Gakkai Zasshi. 1992 May;96(5):652-6.
Thirty-eight cataract eyes and 15 artificial aphakic or pseudophakic eyes were enrolled in this study to determine levels of human epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF) in human aqueous, using a radioimmunoassay. Neither hEGF nor bFGF were detected in either congenital cataract eyes or senile cataract eyes without any complication. In cases of senile cataract complicated with glaucoma and traumatic cataract, bFGF range from 0.4 to 0.8 ng/ml whereas hEGF was not detected. In cases of senile cataract with myocardial or brain infarction and anterior subcapsular cataract, bFGF was detected ranging from 0.4 to 1.0 ng/ml and in some of the cases hEGF was detected at a level of 1.0 ng/ml. hEGF was detected at 1.0 ng/ml in some cases of secondary cataract after uveitis, cataract complicated with retinal detachment, cataract after scleral buckling or vitrectomy, and aphakic or pseudophakic eyes after extracapsular cataract extraction or phacoemulsification. These results showed that hEGF and bFGF exist at a level of about 1 ng/ml in human aqueous in some pathological states and it seems possible that proliferation of lens epithelial cells is promoted by the growth factors, with the result that after cataract, anterior capsular opacities and shrinkage become severe.
本研究纳入了38只白内障眼和15只人工无晶状体眼或假晶状体眼，采用放射免疫分析法测定房水中人表皮生长因子（hEGF）和碱性成纤维细胞生长因子（bFGF）的水平。在无任何并发症的先天性白内障眼或老年性白内障眼中均未检测到hEGF和bFGF。在合并青光眼的老年性白内障和外伤性白内障病例中，bFGF的范围为0.4至0.8 ng/ml，而未检测到hEGF。在合并心肌梗死或脑梗死的老年性白内障和前囊下白内障病例中，检测到bFGF的范围为0.4至1.0 ng/ml，在一些病例中检测到hEGF的水平为1.0 ng/ml。在葡萄膜炎后继发性白内障、合并视网膜脱离的白内障、巩膜扣带术或玻璃体切除术后的白内障以及囊外白内障摘除术或超声乳化术后的无晶状体眼或假晶状体眼的一些病例中，检测到hEGF的水平为1.0 ng/ml。这些结果表明，在某些病理状态下，hEGF和bFGF在人房水中的水平约为1 ng/ml，生长因子似乎有可能促进晶状体上皮细胞的增殖，结果导致白内障后前囊膜混浊和皱缩变得严重。
