Ohashi Y, Motokura M, Kinoshita Y, Mano T, Watanabe H, Kinoshita S, Manabe R, Oshiden K, Yanaihara C
Division of Ophthalmology, Kansai Rosai Hospital, Hyogo, Japan.
Invest Ophthalmol Vis Sci. 1989 Aug;30(8):1879-82.
Epidermal growth factor (EGF) is a polypeptide that stimulates the growth of various tissues, including the cornea. The presence of EGF in tears from normal volunteers and in aqueous humor from cataract patients was investigated via human EGF (hEGF)-specific radioimmunoassay. Immunoreactive hEGF was found to be present at similar concentrations in both reflex (ranging from 0.7 to 8.1 ng/ml) and non-reflex tears (ranging from 1.9 to 9.7 ng/ml), but was undetectable in aqueous humor. Immunoreactive EGF in human tears was indistinguishable immunologically, biologically and biochemically from urine EGF and standard hEGF.
表皮生长因子（EGF）是一种刺激包括角膜在内的各种组织生长的多肽。通过人EGF（hEGF）特异性放射免疫测定法，研究了正常志愿者泪液和白内障患者房水中EGF的存在情况。发现免疫反应性hEGF在反射性泪液（浓度范围为0.7至8.1纳克/毫升）和非反射性泪液（浓度范围为1.9至9.7纳克/毫升）中的浓度相似，但在房水中未检测到。人泪液中的免疫反应性EGF在免疫学、生物学和生物化学方面与尿EGF和标准hEGF无法区分。
