急性冠状动脉综合征中的细胞因子

Cytokines in acute coronary syndromes.

作者信息

Pasqui A L, Di Renzo M, Auteri A, Puccetti L

出版信息

Int J Cardiol. 2005 Dec 7;105(3):355-6. doi: 10.1016/j.ijcard.2005.09.001. Epub 2005 Oct 10.

DOI:10.1016/j.ijcard.2005.09.001

Abstract

The aim of this study was to show the presence of an imbalance between pro-inflammatory and anti-inflammatory mediators in patients affected by acute coronary syndromes (ACS). We evaluated the production in cultured and stimulated lymphomonocytes of interferon (IFN)gamma and tumor necrosis factor (TNF)alpha, which are well known to possess pro-inflammatory effects, and of interleukin (IL)10, which has been shown to have a protective anti-inflammatory activity, in two groups of 30 patients affected by acute myocardial infarction (AMI) and unstable angina (UA), compared with two equivalent groups of patients with stable angina (SA) and of healthy volunteers. We found a significant increase of IFNgamma and TNFalpha production (p<0.01) and a significant decrease of IL-10 production (p<0.01) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls. No significant changes were found between AMI and UA patients and SA patients and controls. We conclude that a relevant imbalance in cytokine release is present in ACS, markedly favoring pro-inflammatory effects.

摘要

本研究的目的是表明急性冠状动脉综合征（ACS）患者体内促炎介质和抗炎介质之间存在失衡。我们评估了两组各30例急性心肌梗死（AMI）和不稳定型心绞痛（UA）患者的培养和刺激淋巴细胞中干扰素（IFN）γ和肿瘤坏死因子（TNF）α的产生情况，这两种物质具有促炎作用，同时还评估了白细胞介素（IL）10的产生情况，IL-10已被证明具有保护性抗炎活性。将这两组患者与两组等量的稳定型心绞痛（SA）患者和健康志愿者进行比较。我们发现，与SA患者和对照组相比，AMI和UA患者淋巴细胞培养物中IFNγ和TNFα的产生显著增加（p<0.01），而IL-10的产生显著减少（p<0.01）。AMI和UA患者与SA患者及对照组之间未发现显著变化。我们得出结论，ACS患者存在细胞因子释放的相关失衡，明显有利于促炎作用。