Hatakeyama Takuji, Ito Shingo, Nakamura Masaharu, Nakamura Eiichi
Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Am Chem Soc. 2005 Oct 19;127(41):14192-3. doi: 10.1021/ja055306q.
A magnesium enamide derived from N-2-(N',N'-diethylamino)ethyl imine reacts with a primary and secondary alkyl chloride or a primary alkyl fluoride to give an alpha-alkylated ketone in good to excellent yield after hydrolysis. The reaction takes place with a high level of inversion of stereochemistry at the electrophilic carbon center and will be useful for production of optically active compounds.
一种由N - 2 -（N'，N' - 二乙氨基）乙基亚胺衍生的镁烯胺与伯卤代烃、仲卤代烃或伯氟代烃反应，水解后能以良好至优异的产率生成α - 烷基化酮。该反应在亲电碳中心具有高度的立体化学翻转，可用于制备光学活性化合物。
