Chilibeck P D, Chrusch M J, Chad K E, Shawn Davison K, Burke D G
College of Kinesiology, University of Saskatchewan, Saskatoon SK, Canada, S7N 5B2.
J Nutr Health Aging. 2005 Sep-Oct;9(5):352-3.
Our purpose was to determine the effects of creatine supplementation combined with resistance training on bone mineral content and density in older men. Twenty-nine older men (age 71 y) were randomized (double blind) to receive creatine (0.3 g/kg creatine for 5 d and 0.07 g/kg thereafter) or placebo while participating in resistance training (12 weeks). Bone mineral content and density were determined by dual energy X-ray absorptiometry before and after training. There was a time main effect for whole-body and leg bone mineral density (p < or = 0.05) with these measures increasing by approximately 0.5%, and 1%, respectively in the combined groups. There was a group by time interaction for arms bone mineral content, with the group receiving creatine increasing by 3.2% (p < 0.01) and the group receiving placebo decreasing by 1.0% (not significant). Changes in lean tissue mass of the arms correlated with changes in bone mineral content of the arms (r = 0.67; p < 0.01). Resistance training of 12 weeks increases bone mineral density in older men and creatine supplementation may provide an additional benefit for increasing regional bone mineral content. The increase in bone mineral content may be due to an enhanced muscle mass with creatine, with potentially greater tension on bone at sites of muscle attachment.
我们的目的是确定补充肌酸并结合抗阻训练对老年男性骨矿物质含量和密度的影响。29名老年男性（71岁）被随机（双盲）分为两组，一组接受肌酸（前5天为0.3 g/kg肌酸，之后为0.07 g/kg），另一组接受安慰剂，同时参与抗阻训练（12周）。在训练前后通过双能X线吸收法测定骨矿物质含量和密度。全身和腿部骨矿物质密度存在时间主效应（p≤0.05），联合组中这些指标分别增加了约0.5%和1%。手臂骨矿物质含量存在组间与时间的交互作用，接受肌酸的组增加了3.2%（p<0.01），接受安慰剂的组下降了1.0%（无显著性差异）。手臂瘦组织质量的变化与手臂骨矿物质含量的变化相关（r = 0.67；p<0.01）。12周的抗阻训练可增加老年男性的骨矿物质密度，补充肌酸可能对增加局部骨矿物质含量有额外益处。骨矿物质含量的增加可能是由于肌酸使肌肉量增加，从而在肌肉附着部位对骨骼产生更大的张力。
