Sellergren Börje, Allender Chris J
INFU, Universität Dortmund, D-44221 Dortmund, Germany.
Adv Drug Deliv Rev. 2005 Dec 6;57(12):1733-41. doi: 10.1016/j.addr.2005.07.010. Epub 2005 Oct 25.
Specific molecular recognition is a fundamental requirement of living systems on which processes as diverse as neural transmittance, respiration, immune defence, cellular differentiation and nutrition rely. It is therefore not surprising that scientists have invested huge amounts of time and effort into harnessing, and more recently mimicking, biological function. A number of synthetic approaches have been developed and one of the most promising of these is molecular imprinting. Molecular imprinted polymers have routinely been used, as robust and effective synthetic molecular receptors, in a diverse range of technologies. But it is perhaps in the area of drug delivery, in particular 'intelligent drug release' and 'magic bullet' drug targeting, that significant future opportunities lie.
特异性分子识别是生命系统的一项基本要求,神经传递、呼吸、免疫防御、细胞分化和营养等各种过程都依赖于此。因此,科学家投入大量时间和精力来利用并在最近模拟生物功能也就不足为奇了。已经开发了许多合成方法,其中最有前景的方法之一是分子印迹。分子印迹聚合物作为强大而有效的合成分子受体,已常规用于各种技术中。但未来重大机遇可能在于药物递送领域,特别是“智能药物释放”和“魔弹”药物靶向。