由遮罩评分者从立体照片检测到的视盘恶化的重测再现性。
Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders.
作者信息
Parrish Richard K, Schiffman Joyce C, Feuer William J, Anderson Douglas R, Budenz Donald L, Wells-Albornoz Maria-Cristina, Vandenbroucke Ruth, Kass Michael A, Gordon Mae O
机构信息
Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
出版信息
Am J Ophthalmol. 2005 Oct;140(4):762-4. doi: 10.1016/j.ajo.2005.04.044.
PURPOSE
To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS).
DESIGN
Test-retest reproducibility study.
METHODS
Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream.
RESULTS
Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%.
CONCLUSIONS
The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
目的
评估在眼压升高治疗研究（OHTS）中，由视盘阅读中心（ODRC）判定眼睛是否发生视盘病变的可重复性。
设计
重测可重复性研究。
方法
ODRC的经过认证的盲态分级人员，通过比较基线期和随访期的视盘立体照片，判定OHTS中视盘病变的发生情况。为评估可重复性，每年通过将盲态的“质量控制”照片插入ODRC常规阅片流程中来进行重新分级。
结果
5年间的一致性（kappa值）范围为0.65至0.83。特异性范围为98%至100%，敏感性范围为64%至81%。
结论
OHTS中重测一致性的kappa统计量在5年间处于公认的良好至优秀范围内。对视盘未发生病变的重新分级的一致性（特异性）特别高。敏感性结果表明，检测视盘的细微病变具有挑战性。
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