Parrish Richard K, Schiffman Joyce C, Feuer William J, Anderson Douglas R, Budenz Donald L, Wells-Albornoz Maria-Cristina, Vandenbroucke Ruth, Kass Michael A, Gordon Mae O
Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Am J Ophthalmol. 2005 Oct;140(4):762-4. doi: 10.1016/j.ajo.2005.04.044.
To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS).
Test-retest reproducibility study.
Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream.
Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%.
The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
评估在眼压升高治疗研究（OHTS）中，由视盘阅读中心（ODRC）判定眼睛是否发生视盘病变的可重复性。
重测可重复性研究。
ODRC的经过认证的盲态分级人员，通过比较基线期和随访期的视盘立体照片，判定OHTS中视盘病变的发生情况。为评估可重复性，每年通过将盲态的“质量控制”照片插入ODRC常规阅片流程中来进行重新分级。
5年间的一致性（kappa值）范围为0.65至0.83。特异性范围为98%至100%，敏感性范围为64%至81%。
OHTS中重测一致性的kappa统计量在5年间处于公认的良好至优秀范围内。对视盘未发生病变的重新分级的一致性（特异性）特别高。敏感性结果表明，检测视盘的细微病变具有挑战性。
