Margolin William
Department of Microbiology and Molecular Genetics, University of Texas Medical School, 6431 Fannin, Houston, Texas 77030, USA.
Nat Rev Mol Cell Biol. 2005 Nov;6(11):862-71. doi: 10.1038/nrm1745.
Binary fission of many prokaryotes as well as some eukaryotic organelles depends on the FtsZ protein, which self-assembles into a membrane-associated ring structure early in the division process. FtsZ is homologous to tubulin, the building block of the microtubule cytoskeleton in eukaryotes. Recent advances in genomics and cell-imaging techniques have paved the way for the remarkable progress in our understanding of fission in bacteria and organelles.
许多原核生物以及一些真核细胞器的二分裂依赖于FtsZ蛋白，该蛋白在分裂过程早期会自我组装成与膜相关的环状结构。FtsZ与微管蛋白同源，微管蛋白是真核生物微管细胞骨架的组成成分。基因组学和细胞成像技术的最新进展为我们在理解细菌和细胞器分裂方面取得显著进展铺平了道路。
