Critchley H O, Wallace W H, Shalet S M, Mamtora H, Higginson J, Anderson D C
Department of Obstetrics and Gynaecology, St. Mary's Hospital, Manchester, UK.
Br J Obstet Gynaecol. 1992 May;99(5):392-4. doi: 10.1111/j.1471-0528.1992.tb13755.x.
To investigate the impact of premature ovarian failure due to whole abdominal radiotherapy (DXT) in childhood on uterine physical characteristics and blood flow and measuring the uterine response to exogenous sex steroid replacement.
A comparative observational study
10 women with premature ovarian failure due to treatment with whole abdominal irradiation in childhood. A comparison group of 22 women with premature ovarian failure who had not received whole abdominal DXT.
Uterine length and uterine blood flow measurement plus serial assessment of endometrial thickness during a cycle of exogenous sex steroid replacement.
Uterine length was significantly less (P less than 0.01) in women who had been exposed to whole abdominal DXT in childhood (mean 4.1 cm, 2SE 0.8) compared with a mean of 7.3 cm (2SE 0.6) in the comparison group. The three women in the DXT group who were studied serially had no increase in endometrial thickness in response to physiological sex steroid replacement therapy and most of the 10 irradiated women had no detectable uterine blood flow with Doppler ultrasound.
Uterine musculature and blood flow are irreversibly affected by high dose irradiation in childhood. Non-invasive assessment of this nature may predict potential for pregnancy following ovum donation and embryo transfer.
探讨儿童期全腹放疗（DXT）所致卵巢早衰对子宫物理特性和血流的影响，并测定子宫对外源性性激素替代治疗的反应。
一项对比观察性研究
10名因儿童期接受全腹照射治疗而导致卵巢早衰的女性。设立一个由22名未接受全腹DXT的卵巢早衰女性组成的对照组。
在外源性性激素替代治疗周期内，测量子宫长度和子宫血流，并连续评估子宫内膜厚度。
与对照组平均7.3 cm（标准误0.6）相比，儿童期接受全腹DXT的女性子宫长度明显较短（P<0.01）（平均4.1 cm，标准误0.8）。对DXT组中3名女性进行连续研究发现，生理性性激素替代治疗后她们的子宫内膜厚度未增加，并且10名接受照射的女性中大多数通过多普勒超声检测不到子宫血流。
儿童期高剂量照射会对子宫肌肉组织和血流产生不可逆的影响。这种性质的非侵入性评估可能预测卵母细胞捐赠和胚胎移植后怀孕的可能性。
