2002年，巴西，登革热3型病毒
Dengue virus type 3, Brazil, 2002.
作者信息
Nogueira Rita Maria Ribeiro, Schatzmayr Hermann Gonçalves, de Filippis Ana Maria Bispo, dos Santos Flávia Barreto, da Cunha Rivaldo Venâncio, Coelho Janice Oliveira, de Souza Luiz José, Guimarães Flávia Ramos, de Araújo Eliane Saraiva Machado, De Simone Thatiane Santos, Baran Meri, Teixeira Gualberto, Miagostovich Marize Pereira
机构信息
Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
出版信息
Emerg Infect Dis. 2005 Sep;11(9):1376-81. doi: 10.3201/eid1109.041043.
During the summer of 2002, Rio de Janeiro had a large epidemic of dengue fever; 288,245 cases were reported. A subset of 1,831 dengue hemorrhagic fever cases occurred. In this study, performed in the first half of 2002, samples from 1,559 patients with suspected cases of dengue infection were analyzed. From this total, 1,497 were obtained from patients with nonfatal cases, and 62 were obtained from patients with fatal cases. By the use of different methods, 831 (53.3%) cases, including 40 fatal cases, were confirmed as dengue infection. When virus identification was successful, dengue virus type 3 (DENV-3) was obtained in 99% of cases. Neurologic involvement was shown in 1 patient with encephalitis, confirmed by the detection of DENV-3 RNA in the cerebrospinal fluid. This explosive epidemic of DENV-3 was the most severe dengue epidemic reported in Brazil since dengue viruses were introduced in 1986.
2002年夏天，里约热内卢爆发了大规模登革热疫情；报告了288,245例病例。其中出现了1,831例登革出血热病例。在这项于2002年上半年开展的研究中，对1,559例疑似登革热感染病例的样本进行了分析。其中，1,497例样本来自非致命病例患者，62例样本来自致命病例患者。通过不同方法，共确诊831例（53.3%）登革热感染病例，其中包括40例致命病例。病毒鉴定成功时，99%的病例检测到登革热3型病毒（DENV-3）。1例脑炎患者出现神经系统受累，脑脊液中检测到DENV-3 RNA得以确诊。自1986年引入登革热病毒以来，此次DENV-3的爆发性疫情是巴西报告的最严重的登革热疫情。
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