SMC复合物在细菌染色体凝聚和分离中的作用。
SMC complexes in bacterial chromosome condensation and segregation.
作者信息
Strunnikov Alexander V
机构信息
NIH, NICHD, Bethesda, MD, USA.
出版信息
Plasmid. 2006 Mar;55(2):135-44. doi: 10.1016/j.plasmid.2005.08.004. Epub 2005 Oct 17.
Abstract
Bacterial chromosomes segregate via a partition apparatus that employs a score of specialized proteins. The SMC complexes play a crucial role in the chromosome partitioning process by organizing bacterial chromosomes through their ATP-dependent chromatin-compacting activity. Recent progress in the composition of these complexes and elucidation of their structural and enzymatic properties has advanced our comprehension of chromosome condensation and segregation mechanics in bacteria.
摘要
细菌染色体通过一个由多种特殊蛋白质组成的分配装置进行分离。SMC复合物在染色体分配过程中发挥着关键作用，它们通过依赖ATP的染色质压缩活性来组织细菌染色体。这些复合物组成方面的最新进展以及其结构和酶学特性的阐明，加深了我们对细菌染色体凝聚和分离机制的理解。
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2
Dynamic assembly, localization and proteolysis of the Bacillus subtilis SMC complex.枯草芽孢杆菌SMC复合物的动态组装、定位及蛋白水解作用
BMC Cell Biol. 2005 Jun 29;6:28. doi: 10.1186/1471-2121-6-28.
3
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Biochem Biophys Res Commun. 2005 Aug 5;333(3):694-702. doi: 10.1016/j.bbrc.2005.05.163.
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