Child Development & Exercise Centre, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Room KB 02.056.0, PO Box 85090, 3508 AB Utrecht, The Netherlands.
Br J Sports Med. 2010 Mar;44(4):270-4. doi: 10.1136/bjsm.2008.048512. Epub 2008 May 16.
The 6-minute walk test (6MWT) is a frequently used indicator of functional exercise capacity. The goals of this study were to compare the 6-minute walk performance of three paediatric patient groups with that of healthy peers, to assess differences between published reference values and to investigate which anthropometric characteristics best predict 6-minute walk performance.
47 children with haemophilia (mean (SD) age 12.5 (2.9) years), 44 with juvenile idiopathic arthritis (JIA) (mean age 9.3 (2.2) years) and 22 with spina bifida (SB) (mean age 10.3 (3.1) years) were included. Subjects performed a 6MWT, and the distance walked (6MWD) was compared with published reference values.
The haemophilia, JIA and SB patients achieved 90%-92%, 72%-75% and 60%-62% of predicted walking distances, respectively. There were significant associations between 6MWD and age, height and weight in the haemophilia group and 6MWD and height in the JIA group. None of the anthropometric variables was significantly related to 6MWD in the SB group. All anthropometric variables were strongly correlated with walking distance-body weight product (6Mwork) in all groups. Height explained 24% (haemophilia) and 11% (JIA) of the variance in 6MWD and 84% (haemophilia), 78% (JIA) and 73% (SB) of the variance in 6Mwork.
Walking distances of children with haemophilia, JIA and SB are significantly reduced compared with healthy references. Walking distance-body weight product seems to be a better outcome measure of the 6MWT compared with distance walked alone. Height is the best predictor of 6MWD and 6Mwork.
6 分钟步行测试（6MWT）是一种常用于评估功能性运动能力的指标。本研究的目的是比较三组儿科患者与健康同龄人的 6 分钟步行表现，评估发表的参考值之间的差异，并探讨哪些人体测量特征能最好地预测 6 分钟步行表现。
共纳入 47 例血友病儿童（平均（标准差）年龄 12.5（2.9）岁）、44 例幼年特发性关节炎（JIA）患儿（平均年龄 9.3（2.2）岁）和 22 例脊柱裂（SB）患儿（平均年龄 10.3（3.1）岁）。受试者进行 6MWT，并将行走距离（6MWD）与发表的参考值进行比较。
血友病、JIA 和 SB 患者的预测行走距离分别为 90%-92%、72%-75%和 60%-62%。在血友病组中，6MWD 与年龄、身高和体重显著相关，在 JIA 组中，6MWD 与身高显著相关。在 SB 组中，没有一个人体测量变量与 6MWD 显著相关。所有组的所有人体测量变量与步行距离-体重乘积（6Mwork）高度相关。身高解释了 6MWD 的 24%（血友病）和 11%（JIA）的变异性，6Mwork 的 84%（血友病）、78%（JIA）和 73%（SB）的变异性。
与健康参考值相比，血友病、JIA 和 SB 患儿的行走距离显著减少。与单独的行走距离相比，行走距离-体重乘积似乎是 6MWT 的更好结果测量指标。身高是 6MWD 和 6Mwork 的最佳预测因子。
