Carter Dan, Olchovsky David, Yonath Hagit, Langevitz Pnina, Ezra David
Internal Medicine, Sheba Medical Center, Tel Hashomer, 52621 Ramat Gan, Israel.
Clin Rheumatol. 2006 Sep;25(5):756-8. doi: 10.1007/s10067-005-0051-y. Epub 2005 Oct 19.
Transverse myelitis is a rare manifestation of antiphospholipid syndrome, usually secondary to systemic lupus erythematosus (Rheum Dis Clin North Am 20:129-158, 1994). Only about 110 reports of this complication have been reported (Lupus 10:851-856, 2001). A connection has been demonstrated between positive serology for antiphospholipid and transverse myelitis (Lupus 8:109-115, 1999). Herein, we report of a young patient admitted with deep vein thrombosis and neurological manifestations of transverse myelitis with negative serology for systemic lupus erythematosus and antiphospholipid, who developed positive anticardiolipin antibody during pulse therapy with cyclophosphamide and methylprednisolone.
横贯性脊髓炎是抗磷脂综合征的一种罕见表现，通常继发于系统性红斑狼疮（《北美风湿病临床》20:129 - 158, 1994）。关于这种并发症的报道仅有约110例（《狼疮》10:851 - 856, 2001）。抗磷脂血清学阳性与横贯性脊髓炎之间的关联已得到证实（《狼疮》8:109 - 115, 1999）。在此，我们报告一名年轻患者，因深静脉血栓形成及横贯性脊髓炎的神经学表现入院，其系统性红斑狼疮和抗磷脂血清学检查均为阴性，在接受环磷酰胺和甲泼尼龙冲击治疗期间出现了抗心磷脂抗体阳性。
