首次体外受精尝试时特发性受精失败的预测价值。
The predictive value of idiopathic failure to fertilize on the first in vitro fertilization attempt.
作者信息
Molloy D, Harrison K, Breen T, Hennessey J
机构信息
Queensland Fertility Group, Watkins Medical Centre, Brisbane, Australia.
出版信息
Fertil Steril. 1991 Aug;56(2):285-9. doi: 10.1016/s0015-0282(16)54486-0.
OBJECTIVE
To investigate the subsequent performance of patients with idiopathic fertilization failure on the first in vitro fertilization (IVF) cycle.
DESIGN
A retrospective study of 2,322 consecutive patients undergoing their initial IVF cycle.
SETTING
Advanced infertility treatment in an IVF/general infertility clinic.
PATIENTS
In 5 years, 94 couples with unexplained failed oocyte fertilization had 270 cycles of treatment. Each couple's performance was tracked through subsequent cycles of treatment.
INTERVENTIONS
In vitro fertilization with husband and donor sperm.
MAIN OUTCOME MEASURE(S): Investigated retrospectively after 5 years of data collection.
RESULTS
Sixty-five couples of the original 94 had a second IVF attempt. Fifty of these successfully fertilized oocytes with husband's sperm and 4 with donor sperm. Nineteen of the 65 couples who continued treatment achieved a pregnancy, and only one couple had continuing fertilization failure.
CONCLUSIONS
The prognosis in the study group was surprisingly favorable despite the initial failed IVF treatment cycle.
目的
调查特发性受精失败患者在首次体外受精（IVF）周期后的后续表现。
设计
对2322例连续进行首次IVF周期的患者进行回顾性研究。
地点
IVF/普通不孕症诊所的高级不孕症治疗。
患者
在5年中，94对不明原因卵母细胞受精失败的夫妇进行了270个治疗周期。通过后续治疗周期跟踪每对夫妇的表现。
干预措施
使用丈夫和供体精子进行体外受精。
主要观察指标
在收集5年数据后进行回顾性调查。
结果
原94对夫妇中的65对进行了第二次IVF尝试。其中50对用丈夫的精子成功使卵母细胞受精，4对用供体精子成功受精。继续治疗的65对夫妇中有19对成功妊娠，只有一对夫妇持续受精失败。
结论
尽管最初的IVF治疗周期失败，但研究组的预后出人意料地良好。
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