de Lau Lonneke M L, Koudstaal Peter J, Hofman Albert, Breteler Monique M B
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Ann Neurol. 2005 Nov;58(5):797-800. doi: 10.1002/ana.20663.
In a prospective population-based cohort study among 4,695 participants aged 55 years and older, with repeated in-person examination and on average 9.4 years of follow-up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51-0.98]), with evidence for a dose-effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid.
在一项针对4695名55岁及以上参与者的基于人群的前瞻性队列研究中，通过反复的面对面检查和平均9.4年的随访，我们观察到较高的血清尿酸水平与帕金森病风险显著降低相关（每标准差增加的调整后风险比为0.71 [95%置信区间0.51 - 0.98]），并有证据表明存在剂量效应关系（四分位数趋势的p值为0.040）。我们的研究结果支持氧化应激导致帕金森病风险增加的假说，并提示天然抗氧化剂和自由基清除剂尿酸可能具有保护作用。
