Dugoujon J M, Guitard E, Senegas M T
CRPG-CNRS, CHU Purpan, Toulouse, France.
G Ital Cardiol. 1992 Jan;22(1):85-95.
The associations or linkages between the polymorphisms of the Gm and Km immunoglobulin allotypes and the susceptibility to autoimmune diseases, including diseases with immuno-pathological pathogenesis are reported in this review. These diseases include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, insulin-dependent diabetes mellitus, Crohn's disease, coeliac disease, Graves' disease, atrophic thyroiditis, Hashimoto's thyroiditis, myasthenia gravis, chronic active hepatitis, alopecia areata, uveitis, vitiligo, Turner's syndrome, glomerular nephritis, Berger's disease and idiopathic dilated cardiomyopathy. Immunoglobulin allotypes are described as well as the statistical methods used to analyse the data.
本综述报道了Gm和Km免疫球蛋白同种异型的多态性与自身免疫性疾病易感性之间的关联或联系，这些自身免疫性疾病包括具有免疫病理发病机制的疾病。这些疾病包括多发性硬化症、类风湿性关节炎、系统性红斑狼疮、胰岛素依赖型糖尿病、克罗恩病、乳糜泻、格雷夫斯病、萎缩性甲状腺炎、桥本甲状腺炎、重症肌无力、慢性活动性肝炎、斑秃、葡萄膜炎、白癜风、特纳综合征、肾小球肾炎、伯杰氏病和特发性扩张型心肌病。文中还描述了免疫球蛋白同种异型以及用于分析数据的统计方法。
