Schmidt W, Königstedt B, Zipprich B, Scheibe E, Nilius R
Department of Internal Medicine I, Martin-Luther-University, Halle-Wittenberg.
Hepatogastroenterology. 1987 Oct;34(5):206-11.
The immunoglobulin allotypes Gm (a; x; f) and Km 1 have been estimated in 194 patients with chronic liver disease, and compared with the frequency distribution of a representative reference group (Gm : n = 2171; Km : n = 2179). In relation to the Gm phenotypes we have investigated the cell-mediated immunoreactivity by the E rosette test, lymphocyte transformation test and migration inhibition test. Virus-induced chronic liver disease showed significantly higher prevalence of the phenotypes Gm a+x-f+ and Gm a+x+f+ as well as of the marker Km + 1 (p less than or equal to 5%; chi 2-test). In auto-immune chronic liver disease we observed a decrease in the phenotype Gm a+x-f+ while the factor Km + 1 was significantly multiplied. Patients with cryptogenic and alcoholic hepatopathy showed no differences in comparison with the reference group. In the progressive forms of the chronic liver disease (chronic active hepatitis, liver cirrhosis) Gm a+x+f+ was significantly more frequent. The investigations concerning cell-mediated immunity in different Gm allotypes generally showed a trend to increased reactivity in Gm a+x+ in comparison with Gm a-x- in non-alcoholic liver disease. It is possible to presume different genetic and immunologic situations in the various liver diseases as endogenous factors promoting the disease.
对194例慢性肝病患者的免疫球蛋白同种异型Gm(a;x;f)和Km 1进行了评估，并与一个代表性参考组（Gm：n = 2171；Km：n = 2179）的频率分布进行了比较。关于Gm表型，我们通过E花环试验、淋巴细胞转化试验和迁移抑制试验研究了细胞介导的免疫反应性。病毒诱导的慢性肝病显示Gm a+x-f+和Gm a+x+f+表型以及标记物Km + 1的患病率显著更高（p≤5%；卡方检验）。在自身免疫性慢性肝病中，我们观察到Gm a+x-f+表型减少，而Km + 1因子显著增加。隐源性和酒精性肝病患者与参考组相比无差异。在慢性肝病的进展形式（慢性活动性肝炎、肝硬化）中，Gm a+x+f+明显更常见。关于不同Gm同种异型中细胞介导免疫的研究总体上显示，与非酒精性肝病中的Gm a-x-相比，Gm a+x+中的反应性有增加的趋势。可以推测，各种肝病中存在不同的遗传和免疫状况，作为促进疾病的内源性因素。
