黄荆种子的化学研究及抗炎活性

Chemical investigation and anti-inflammatory activity of Vitex negundo seeds.

作者信息

Chawla A S, Sharma A K, Handa S S, Dhar K L

机构信息

Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

出版信息

J Nat Prod. 1992 Feb;55(2):163-7. doi: 10.1021/np50080a002.

DOI:10.1021/np50080a002

PMID:1624939

Abstract

The CHCl3 extract of the defatted seeds of Vitex negundo exhibited anti-inflammatory activity and yielded four triterpenoids: 3 beta-acetoxyolean-12-en-27-oic acid [1], 2 alpha, 3 alpha-dihydroxyoleana-5,12-dien-28-oic acid [2], 2 beta,3 alpha-diacetoxyoleana-5,12-dien-28-oic acid [3], and 2 alpha,3 beta-diacetoxy-18-hydroxyoleana-5,12-dien-28-oic acid [5]. This is the first report of the isolation of compounds 2, 3, and 5 from a natural source.

摘要

黄荆脱脂种子的氯仿提取物具有抗炎活性，并产生了四种三萜类化合物：3β-乙酰氧基齐墩果-12-烯-27-酸[1]、2α,3α-二羟基齐墩果-5,12-二烯-28-酸[2]、2β,3α-二乙酰氧基齐墩果-5,12-二烯-28-酸[3]和2α,3β-二乙酰氧基-18-羟基齐墩果-5,12-二烯-28-酸[5]。这是首次从天然来源分离出化合物2、3和5的报道。