Ateş Yüksel, Aslan Murat, Tüzün Ahmet, Bağci Sait, Dağalp Kemal
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey.
Turk J Gastroenterol. 2004 Dec;15(4):263-5.
It is well known that there may be an increased tendency for thrombosis in inflammatory bowel disease (IBD). This study presents a case with antiphospholipid antibody syndrome with ulcerative colitis diagnosed during pregnancy. A 30-year-old female patient, in her 6th week of pregnancy, applied to our clinic with complaints of abdominal pain and bloody diarrhea. She had a history of three abortions. She had been given aspirin and heparin treatment due to high levels of anticardiolipin antibody (ACA) in previous examinations that led to the diagnosis of antiphospholipid antibody syndrome. As the left colonoscopic examination of the patient showed ulcerative colitis, aspirin treatment was replaced with mesalazine (750 mg/day, in 3 equal doses). There was a significant relief in complaints of the patient. Medical treatment was interrupted three days before delivery. The patient delivered a baby, at full-term, of 3.6 kg by cesarean section. No adverse effects were observed in the mother or the baby due to the medical treatment. After delivery, mesalazine treatment was restarted. This case is interesting due to the co-diagnosis of IBD in a pregnant woman with antiphospholipid antibody syndrome. Successful and uncomplicated treatment of the patient with mesalazine should also be noted.
众所周知，炎症性肠病（IBD）患者可能有血栓形成倾向增加的情况。本研究报告了一例在妊娠期诊断为抗磷脂抗体综合征合并溃疡性结肠炎的病例。一名30岁女性患者，妊娠第6周，因腹痛和血性腹泻前来我院就诊。她有三次流产史。之前的检查因抗心磷脂抗体（ACA）水平高导致诊断为抗磷脂抗体综合征，她接受过阿司匹林和肝素治疗。由于患者左半结肠结肠镜检查显示为溃疡性结肠炎，阿司匹林治疗被美沙拉嗪替代（750毫克/天，分3等份剂量）。患者的症状有明显缓解。分娩前三天中断药物治疗。患者剖宫产分娩一名足月3.6千克的婴儿。药物治疗未对母亲或婴儿造成不良影响。产后，重新开始美沙拉嗪治疗。该病例因一名患有抗磷脂抗体综合征的孕妇同时诊断为IBD而有趣。同时也应注意到患者使用美沙拉嗪成功且未出现并发症的治疗情况。
