利用生姜提取物合成的绿色 CrO 纳米粒子辅助微波制备多取代咪唑。

Department of Inorganic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran.

Department of Inorganic Chemistry, Faculty of Chemistry, Semnan University, Semnan, Iran.

Sci Rep. 2022 Nov 19;12(1):19942. doi: 10.1038/s41598-022-24364-6.

CrO nanoparticles were prepared using Zingiber officinal extract which were used as an efficient and reusable catalyst in the practical synthesis of polysubstituted imidazoles by means of a convenient reaction of aromatic aldehydes with ammonium acetate and benzil under microwave irradiation and HO as solvent. The structure of the compounds was studied by IR and H-NMR spectrum. The most important benefits of this process are operational simplicity, reasonable reaction times, and excellent yield of products. The results show that the optimal conditions for the formation of imidazole derivatives are as follow: power of 400 W, reaction time of 4-9 min, HO as a solvent, and 15 mmol of catalyst amount.

CrO 纳米粒子是使用生姜提取物制备的，它在微波辐射下，以 HO 为溶剂，用乙酸铵和二苯甲酮与芳香醛反应，方便地合成多取代咪唑的实际合成中可用作高效且可重复使用的催化剂。通过 IR 和 H-NMR 光谱研究了化合物的结构。该过程的最重要优点是操作简单、反应时间合理和产物收率高。结果表明，形成咪唑衍生物的最佳条件如下：功率为 400 W，反应时间为 4-9 分钟，HO 为溶剂，催化剂用量为 15 mmol。