Grönroos J M, Kuttila K, Nevalainen T J
Department of Surgery, University of Turku, Finland.
Crit Care Med. 1994 Jun;22(6):956-9. doi: 10.1097/00003246-199406000-00013.
To study the association of increased serum group II phospholipase A2 concentrations to C-reactive protein concentrations in the sera of critically ill surgical patients.
Prospective study.
Surgical intensive care unit (ICU) of a university hospital.
Sixty-seven consecutive patients admitted to the surgical ICU.
The catalytic activity of phospholipase A2 and the serum concentrations of group II phospholipase A2 and C-reactive protein were measured daily during each patient's stay in the ICU. A total of 205 blood samples were taken. In addition, the preoperative serum levels of group II phospholipase A2 were determined in patients admitted for cardiac surgery.
Serum group II phospholipase A2 values correlated statistically significantly with the catalytic activity of phospholipase A2 and serum C-reactive protein values. In particular, severe infections, diseases involving tissue destruction, and elective operations per se, caused considerable increases in serum group II phospholipase A2 concentrations.
Our results support the earlier presented idea that group II phospholipase A2 is an acute-phase reactant.
研究重症外科患者血清中Ⅱ型磷脂酶A2浓度升高与C反应蛋白浓度之间的关联。
前瞻性研究。
一所大学医院的外科重症监护病房（ICU）。
67例连续入住外科ICU的患者。
在每位患者入住ICU期间，每天测量磷脂酶A2的催化活性以及血清中Ⅱ型磷脂酶A2和C反应蛋白的浓度。共采集了205份血样。此外，对接受心脏手术的患者测定术前血清Ⅱ型磷脂酶A2水平。
血清Ⅱ型磷脂酶A2值与磷脂酶A2的催化活性及血清C反应蛋白值在统计学上显著相关。特别是严重感染、涉及组织破坏的疾病以及择期手术本身，会导致血清Ⅱ型磷脂酶A2浓度显著升高。
我们的结果支持了之前提出的观点，即Ⅱ型磷脂酶A2是一种急性期反应物。
