Meadows G G, Wallendal M, Kosugi A, Wunderlich J, Singer D S
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Alcohol Clin Exp Res. 1992 Jun;16(3):474-9. doi: 10.1111/j.1530-0277.1992.tb01403.x.
Treatment of mice in vivo with 5% w/v ethanol given in a liquid diet causes marked changes in spleen, peripheral blood, and thymus lymphocytes. In both the thymus and spleen, there is an acute cellular depletion resulting in a significant decrease in gross tissue size and cell number. In spleen and peripheral blood, the percentage of T lymphocytes is increased relative to B lymphocytes, but the ratio of CD4+/CD8+ T cell sub-populations remains unchanged. Splenic natural killer (NK) cell activity is increased in ethanol-consuming mice, although the percentage of NK1.1+ cells is relatively unchanged.
用含5%（重量/体积）乙醇的液体饲料对小鼠进行体内治疗，会导致脾脏、外周血和胸腺淋巴细胞发生显著变化。在胸腺和脾脏中，均出现急性细胞耗竭，导致总体组织大小和细胞数量显著减少。在脾脏和外周血中，T淋巴细胞相对于B淋巴细胞的百分比增加，但CD4+/CD8+ T细胞亚群的比例保持不变。尽管NK1.1+细胞的百分比相对不变，但在摄入乙醇的小鼠中，脾脏自然杀伤（NK）细胞活性增加。
