Klein Christoph, Foerster Friedrich, Hartnegg Klaus, Fischer Burkhart
School of Psychology, University of Wales, Bangor, The Brigantia Building, Penrallt Road, Bangor, Gwynedd LL57 2AS, Wales, UK.
Brain Res Dev Brain Res. 2005 Dec 7;160(2):113-23. doi: 10.1016/j.devbrainres.2005.06.011. Epub 2005 Nov 2.
The comparative study of anti- and pro-saccade task performance contributes to our functional understanding of the frontal lobes, their alterations in psychiatric or neurological populations, and their changes during the life span. In the present study, we apply regression analysis to model life span developmental effects on various pro- and anti-saccade task parameters, using data of a non-representative sample of 327 participants aged 9 to 88 years. Development up to the age of about 27 years was dominated by curvilinear rather than linear effects of age. Furthermore, the largest developmental differences were found for intra-subject variability measures and the anti-saccade task parameters. Ageing, by contrast, had the shape of a global linear decline of the investigated saccade functions, lacking the differential effects of age observed during development. While these results do support the assumption that frontal lobe functions can be distinguished from other functions by their strong and protracted development, they do not confirm the assumption of disproportionate deterioration of frontal lobe functions with ageing. We finally show that the regression models applied here to quantify life span developmental effects can also be used for individual predictions in applied research contexts or clinical practice.
对正扫视任务和反扫视任务表现的比较研究有助于我们从功能上理解额叶，了解其在精神或神经人群中的变化以及在整个生命周期中的改变。在本研究中，我们应用回归分析来模拟生命周期发育对各种正扫视和反扫视任务参数的影响，使用了来自327名年龄在9至88岁之间的非代表性样本的数据。大约27岁之前的发育主要受年龄的曲线效应而非线性效应主导。此外，在个体内变异性测量和反扫视任务参数方面发现了最大的发育差异。相比之下，衰老表现为所研究扫视功能的整体线性下降，缺乏发育过程中观察到的年龄差异效应。虽然这些结果确实支持了额叶功能因其强烈且持久的发育而可与其他功能区分开来的假设，但它们并未证实额叶功能随衰老不成比例恶化的假设。我们最终表明，这里应用的用于量化生命周期发育效应的回归模型也可用于应用研究背景或临床实践中的个体预测。
