Uetani Mirei, Suwazono Yasushi, Kobayashi Etsuko, Inaba Takeya, Oishi Mitsuhiro, Nogawa Koji
Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuohku, Chiba 260-8670, Japan.
Occup Med (Lond). 2006 Mar;56(2):83-8. doi: 10.1093/occmed/kqi178. Epub 2005 Nov 2.
Hyperuricemia is a lifestyle-related disease. Although there have been many previous reports about the association of serum uric acid (UA) levels with lifestyle, including eating habits and alcohol intake, there has been no report of a longitudinal study of the relationship between serum UA levels and shift work.
To clarify the influence of shift work on serum UA levels in Japanese workers.
This was a 4-year cohort study of 15 871 workers at a telecommunications company. Pooled logistic regression analyses by sex were performed, with job schedule type, age, body mass index (BMI), lifestyle and the results of blood chemistries as covariates.
In males, shift work, part-time work, BMI, consumption of alcohol (less than twice per week, two to five times per week or more than five times per week) and little preference for vegetables were positively associated with the development of increased serum UA (>or=8 mg/dl in males, >or=6 mg/dl in females). In females, age, BMI and a history of smoking were positively associated with the development of increased serum UA.
This study revealed that shift work is independently related to increased serum UA in males.
高尿酸血症是一种与生活方式相关的疾病。尽管此前已有许多关于血清尿酸（UA）水平与生活方式（包括饮食习惯和酒精摄入）之间关联的报道，但尚无关于血清UA水平与轮班工作关系的纵向研究报告。
阐明轮班工作对日本工人血清UA水平的影响。
这是一项对一家电信公司15871名工人进行的为期4年的队列研究。按性别进行汇总逻辑回归分析，将工作时间表类型、年龄、体重指数（BMI）、生活方式和血液化学检查结果作为协变量。
在男性中，轮班工作、兼职工作、BMI、饮酒（每周少于两次、每周两至五次或每周超过五次）以及对蔬菜的偏好较低与血清UA升高（男性≥8mg/dl，女性≥6mg/dl）的发生呈正相关。在女性中，年龄、BMI和吸烟史与血清UA升高的发生呈正相关。
本研究表明，轮班工作与男性血清UA升高独立相关。
