Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea.
J Occup Health. 2021 Jan;63(1):e12266. doi: 10.1002/1348-9585.12266.
Long working hours are linked to an increased risk of exposure to work safety hazards that threaten the health of workers. To date, only a few cross-sectional studies regarding the relationship between working characteristics, such as over-workload and chronic kidney disease (CKD) have been reported. Therefore, in this longitudinal study, we aimed to examine the direct relationship between long working hours and the incidence of CKD.
We included 97 856 participants without CKD in the Kangbuk Samsung Health Study. Using a self-report questionnaire, we evaluated weekly working hours, which were categorized into 35-40, 41-52, and >52 hours. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m . Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CKD were estimated using Cox proportional hazards regression analyses with weekly working 35-40 hours as the reference.
During a median follow-up of 4.0 years, 185 participants developed incident CKD (incidence density, 4.83 per 10 person-years). Multivariable-adjusted HRs (95% CI) of incident CKD for weekly working >52 hours compared with working 35-40 hours were 1.99 (1.22-3.25). In subgroup analyses, the significant association between working >52 hours and incident CKD was consistently observed in groups of age ≥40 years, men, and obesity with no interaction.
Our large-scale cohort study of young- to middle-aged men and women demonstrated a significant association between long working hours and an increased risk of incident CKD.
长时间工作与接触威胁工人健康的工作安全危害的风险增加有关。迄今为止,仅有少数关于工作特征(如过度劳累和慢性肾脏病(CKD))与 CKD 之间关系的横断面研究报告。因此,在这项纵向研究中,我们旨在检验长工作时间与 CKD 发病之间的直接关系。
我们纳入了来自 Kangbuk Samsung 健康研究的 97856 名无 CKD 的参与者。使用自我报告问卷,我们评估了每周工作时间,分为 35-40、41-52 和>52 小时。CKD 的定义为估计肾小球滤过率<60 mL/min/1.73 m 。使用 Cox 比例风险回归分析,以每周工作 35-40 小时为参照,估计 CKD 发病的危害比(HR)和 95%置信区间(CI)。
在中位随访 4.0 年期间,185 名参与者发生了 CKD(发病率密度为 4.83/10 人年)。与每周工作 35-40 小时相比,每周工作>52 小时发生 CKD 的多变量调整 HR(95%CI)为 1.99(1.22-3.25)。在亚组分析中,在年龄≥40 岁、男性和肥胖的人群中,工作>52 小时与 CKD 发病之间的显著关联始终存在,且无交互作用。
我们对年轻到中年男性和女性的大规模队列研究表明,长时间工作与 CKD 发病风险增加之间存在显著关联。