Stern P, Levine N
Section of Dermatology, University of Arizona Health Sciences Center, Tucson 85724.
Arch Dermatol. 1992 Jul;128(7):945-8.
Controlled localized heating as a method of superficial tissue destruction has been used in veterinary medicine for the treatment of benign and malignant tumors. The rationale for its use is that the diseased tissue being treated is more sensitive to the effects of heating than is normal tissue. This technology was applied to the treatment of common hand warts in a placebo-controlled study.
Twenty-nine warts were treated one to four times (median, two times) at 50 degrees C for 30 to 60 seconds. Twenty-five (86%) of 29 treated verrucae regressed completely while seven (41%) of 17 control warts resolved during the course of the study. No wart that regressed regrew during the follow-up period (mean, 15.6 weeks).
Controlled localized heating can cause the regression of hand warts. The 86% regression rate compares favorably with other wart treatment modalities. The mechanism of action and the effect of heat on these virally induced tumors is not known but may involve direct antiviral effects, physical destruction of the tumor, or the promotion of an inflammatory response that ultimately eradicates the lesion.
可控局部加热作为一种浅表组织破坏方法，已在兽医学中用于治疗良性和恶性肿瘤。其使用原理是，接受治疗的患病组织比正常组织对加热效应更敏感。这项技术被应用于一项安慰剂对照研究中，用于治疗常见的手部疣。
29个疣接受了1至4次（中位数为2次）治疗，在50摄氏度下加热30至60秒。29个接受治疗的疣中有25个（86%）完全消退，而17个对照疣中有7个（41%）在研究过程中消退。在随访期（平均15.6周）内，没有一个消退的疣复发。
可控局部加热可使手部疣消退。86%的消退率优于其他疣治疗方式。加热对这些病毒诱导肿瘤的作用机制尚不清楚，但可能涉及直接抗病毒作用、肿瘤的物理破坏，或促进最终根除病变的炎症反应。
