Perri R, Carlesimo G A, Serra L, Caltagirone C
Fondazione IRCCS Santa Lucia, Rome, Italy.
J Clin Exp Neuropsychol. 2005 Nov;27(8):1033-55. doi: 10.1080/13803390490919317.
Different aspects of episodic long-term, short-term and implicit long-term memory were investigated in subjects who strictly fulfilled the criteria for the amnestic form of Mild Cognitive Impairment (a-MCI). Results showed normal short-term memory abilities in these subjects, while each of the episodic long-term memory indices explored showed poorer results in a-MCI subjects with respect to normal controls. Although some episodic memory functions were relatively well preserved, others appeared to have deteriorated to a level comparable to that of mild AD patients. The finding of an extensive impairment of all memory functions depending on hippocampal structures in a population with a high risk of developing dementia is strongly supportive of the hypothesis that a pure amnesic syndrome characterizes the preclinical phase of AD.
在严格符合遗忘型轻度认知障碍（a-MCI）标准的受试者中，对情景长期记忆、短期记忆和内隐长期记忆的不同方面进行了研究。结果显示，这些受试者的短期记忆能力正常，而所探究的每个情景长期记忆指标在a-MCI受试者中相对于正常对照组均表现出较差的结果。尽管一些情景记忆功能相对保存完好，但其他功能似乎已恶化到与轻度AD患者相当的水平。在具有高痴呆风险的人群中，发现所有依赖海马结构的记忆功能广泛受损，这有力地支持了以下假设：纯遗忘综合征是AD临床前期的特征。
