多中心自动除颤器植入试验-心脏再同步治疗（MADIT-CRT）：设计与临床方案
Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol.
作者信息
Moss Arthur J, Brown Mary W, Cannom David S, Daubert James P, Estes Mark, Foster Elyse, Greenberg Henry M, Hall W Jackson, Higgins Steven L, Klein Helmut, Pfeffer Mark, Wilber David, Zareba Wojciech
机构信息
Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
出版信息
Ann Noninvasive Electrocardiol. 2005 Oct;10(4 Suppl):34-43. doi: 10.1111/j.1542-474X.2005.00073.x.
Abstract
The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF<or=0.30), and prolonged intraventricular conduction (QRS duration>or=130 ms).
摘要
计划中的MADIT-CRT试验旨在确定心脏再同步化治疗除颤器（CRT-D）是否能将患有缺血性（纽约心脏协会I-II级）和非缺血性（纽约心脏协会II级）心肌病、左心室功能障碍（射血分数≤0.30）以及室内传导延长（QRS时限≥130毫秒）的受试者的死亡风险和心力衰竭事件风险降低约25%。
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