Parada Meire B, Michalany Nílceo S, Hassun Karime M, Bagatin Ediléia, Talarico Sérgio
Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil.
Skinmed. 2005 Nov-Dec;4(6):345-9. doi: 10.1111/j.1540-9740.2005.04061.x.
This study was designed to describe the histologic aspects of the cutaneous and mucosal adverse reactions to fillers used for cosmetic purposes.
Eleven specimens of adverse reactions caused by Restylane, Artecoll, Metacril, New-Fill, Aquamid, and liquid silicone were processed and stained by hematoxylin-eosin and Alcian blue and submitted to polarized light.
Most of the reactions were foreign-body granulomas.
The type of granuloma and the characteristics of the agent were determined, contributing to the histologic identification of the material used. In the cases involving Restylane and Aquamid, it was possible to identify the material using Alcian blue stain and by the presence of necrosis. This stain was strongly positive in Restylane and faintly positive in Aquamid, and intense necrosis was observed in Aquamid cases. In the other cases the filler material itself was recognized and identified.
本研究旨在描述用于美容目的的填充剂引起的皮肤和黏膜不良反应的组织学特征。
对由瑞蓝、爱贝芙、美特瑞、纽弗、奥美定和液体硅胶引起的11例不良反应标本进行苏木精-伊红染色和阿尔辛蓝染色，并进行偏振光观察。
大多数反应为异物肉芽肿。
确定了肉芽肿类型和填充剂特征，有助于对所用材料进行组织学鉴定。在涉及瑞蓝和奥美的病例中，通过阿尔辛蓝染色及坏死情况可识别材料。该染色在瑞蓝中呈强阳性，在奥美定中呈弱阳性，且奥美定病例中观察到严重坏死。在其他病例中，可识别并鉴定填充材料本身。
