Zimmermann Ute S, Clerici Thierry J
SCP d'Histopathologie, Paris, France.
Semin Cutan Med Surg. 2004 Dec;23(4):241-50. doi: 10.1016/j.sder.2004.09.004.
The histological aspects of resorbable heterologous fillers (bovine collagen, acid hyaluronique), autologous fillers (lipofilling, dermis-fat graft), biodegradable fillers (New-Fill), and permanent fillers (silicone, Artecoll, Evolution, Aquamid, DermaLive, DermaDeep, Bioplastique, Paraffin) are described. This article relates the morphological aspect of these materials, the normal tissue reaction after injection, and its chronological evolution as the morphological aspects from the different side effects, more frequently observed for the permanent fillers. They mainly consist of granulomatous reactions which may appear long after injection.
本文描述了可吸收异源填充剂（牛胶原蛋白、透明质酸）、自体填充剂（脂肪填充、真皮脂肪移植）、可生物降解填充剂（New - Fill）和永久性填充剂（硅胶、爱贝芙、Evolution、Aquamid、DermaLive、DermaDeep、Bioplastique、石蜡）的组织学方面。本文阐述了这些材料的形态学方面、注射后的正常组织反应及其随时间的演变，以及不同副作用的形态学表现，永久性填充剂更常出现这些副作用。它们主要由肉芽肿反应组成，这些反应可能在注射后很长时间才出现。
