Sun Li-Min, Epplein Meira, Li Christopher I, Vaughan Thomas L, Weiss Noel S
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Am J Epidemiol. 2005 Dec 15;162(12):1174-8. doi: 10.1093/aje/kwi345. Epub 2005 Nov 9.
Nasopharyngeal carcinoma is much more common in Asian countries than in Western countries. However, since the 1980s, nasopharyngeal carcinoma incidence has fallen among both men and women in Hong Kong, and recently a similar trend has also been noted in Singapore. Using data from the Surveillance, Epidemiology, and End Results Program and the US Census, the authors evaluated recent trends in the incidence rates of nasopharyngeal carcinoma among Chinese living in Los Angeles County and in the San Francisco-Oakland (California) metropolitan area. From 1992 to 2002, the rates of nasopharyngeal carcinoma in these two populations decreased in men by 37% (95% confidence interval: -54, -12) but in women by just 1% (95% confidence interval: -40, 64). In Chinese men, the overall decline in incidence was limited primarily to a decline in the rate of type I tumors (differentiated squamous tumors with keratin production). While the reasons underlying the observed patterns of incidence remain to be determined, changes in lifestyle and environment are likely to be contributory factors.
鼻咽癌在亚洲国家比在西方国家更为常见。然而，自20世纪80年代以来，香港男性和女性的鼻咽癌发病率均有所下降，最近新加坡也出现了类似趋势。作者利用监测、流行病学和最终结果计划以及美国人口普查的数据，评估了居住在洛杉矶县和旧金山-奥克兰（加利福尼亚州）大都市区的华裔人群中鼻咽癌发病率的近期趋势。1992年至2002年，这两个人群中男性的鼻咽癌发病率下降了37%（95%置信区间：-54，-12），而女性仅下降了1%（95%置信区间：-40，64）。在华裔男性中，发病率的总体下降主要局限于I型肿瘤（产生角蛋白的分化鳞状肿瘤）发病率的下降。虽然观察到的发病模式背后的原因仍有待确定，但生活方式和环境的变化可能是促成因素。
